By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
Like a Trojan horse, liposome carriers clodronate to the target cell where it is ingested by the macrophages. This then releases the drug into the cell and the inhibition of the macrophages activities is achieved by bisphosphonates (the active components in it). Though the idea looks simple, researchers are upbeat that this will be the best cure for most stubborn immune diseases.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
As with every most bisphosphonates, there are no major side effects associated with Clodronate. In fact, it is expected to have similar effects that other drugs in this category have shown. For instance, those undergoing treatment against high calcium levels in the blood do complain of mild stomach pains, nausea and vomiting. Other mild side effects include diarrhea and loss of appetite.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Clodronate products may also lead to swelling, mouth pain and malaise. As mentioned before, you need the attention of a physician. Since the drug is not in the market currently, you do not need to judge it by these pre-release precautionary measures. It is possible that the drug will turn out just fine.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
Clodronate liposome as mentioned before is a prescription drug and thus cannot be shared with a family member, even if they have the same conditions. On the other hand, one cannot use the drugs unless the doctor prescribes it. Once it is officially released, it is expected to bring the much-needed cure for cancer. However, success will depend on how strict the patients will follow the prescription of the doctor.
Like a Trojan horse, liposome carriers clodronate to the target cell where it is ingested by the macrophages. This then releases the drug into the cell and the inhibition of the macrophages activities is achieved by bisphosphonates (the active components in it). Though the idea looks simple, researchers are upbeat that this will be the best cure for most stubborn immune diseases.
Though still in the trial stages, the drug has shown a lot of success and will help in the treatment of cancer, osteoporosis and autoimmune hemolytic anemia. Metastatic carcinoma of the breast and multiple myeloma are among other conditions that the drug will be able to handle. On the other hand, this drug has shown success with the suppression of macrophage activities in neurological disorders, gene therapy and transplantation.
As with every most bisphosphonates, there are no major side effects associated with Clodronate. In fact, it is expected to have similar effects that other drugs in this category have shown. For instance, those undergoing treatment against high calcium levels in the blood do complain of mild stomach pains, nausea and vomiting. Other mild side effects include diarrhea and loss of appetite.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Clodronate products may also lead to swelling, mouth pain and malaise. As mentioned before, you need the attention of a physician. Since the drug is not in the market currently, you do not need to judge it by these pre-release precautionary measures. It is possible that the drug will turn out just fine.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
Clodronate liposome as mentioned before is a prescription drug and thus cannot be shared with a family member, even if they have the same conditions. On the other hand, one cannot use the drugs unless the doctor prescribes it. Once it is officially released, it is expected to bring the much-needed cure for cancer. However, success will depend on how strict the patients will follow the prescription of the doctor.
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Companies and business clients can now order clodronate liposome directly from the following website www.clodrosome.com. To see a full list of our products, go to this page at http://www.clodrosome.com.
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